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Diclofenac
Clinical data
Trade namesCataflam, Voltaren, see trade names [1]
AHFS/Drugs.comMonograph
MedlinePlusa689002
Pregnancy categoryAU: C US: C (Risk not ruled out) in 1st and 2nd trimester, D in 3rd trimester
Routes of administrationoral, rectal, intramuscular, intravenous (renal- and gallstones), topical
ATC codeD11AX18 ( WHO ) M01AB05 ( WHO ), M02AA15 ( WHO ), S01BC03 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) – S4, UK: POM (Prescription only) (P for topical formulation), ℞-only in most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures
Protein bindingMore than 99%
Metabolismhepatic, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation; [2] no active metabolites exist
Elimination half-life1.2–2 hr (35% of the drug enters enterohepatic recirculation)
Excretion40% biliary 60% urine

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