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Sibutramine (top), ( S )-(−)-sibutramine (bottom)
Clinical data
Trade namesMeridia, others
Pregnancy categoryAU: C US: C (Risk not ruled out) No human data exists; inconclusive evidence of teratogenic potential in animal studies
Routes of administrationOral (capsules)
ATC codeA08AA10 ( WHO )
Legal status
Legal statusUS: Schedule IV
BioavailabilityAbsorption 77%, considerable first-pass metabolism
Protein binding97%, (94% for its desmethyl metabolites, M 1 & M 2 )
MetabolismHepatic (CYP3A4-mediated)
Elimination half-life1 hour (sibutramine), 14 hours (M 1 ) & 16 hours (M 2 )
ExcretionUrine (77%), feces (8%)

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